Kazuki Tajima Selected Research

3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanol

10/2020	Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor.
1/2020	Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
1/2017	Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.

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Kazuki Tajima Research Topics

Disease

6	Insulin Resistance 11/2021 - 05/2014
6	Type 2 Diabetes Mellitus (MODY) 11/2021 - 07/2011
5	Fatty Liver 11/2021 - 07/2012
4	Inflammation (Inflammations) 11/2021 - 01/2016
4	Keratitis 01/2019 - 05/2013
3	Non-alcoholic Fatty Liver Disease 11/2021 - 11/2011
3	Body Weight (Weight, Body) 11/2021 - 02/2016
3	Obstructive Sleep Apnea 06/2017 - 06/2014
2	Glucose Intolerance 10/2020 - 01/2019
2	Atrophy 10/2020 - 01/2020
2	Wounds and Injuries (Trauma) 01/2020 - 07/2018
2	Hemorrhage 06/2019 - 01/2019
2	Thrombosis (Thrombus) 01/2019 - 01/2016
2	Obesity 01/2019 - 01/2019
2	Insulinoma 01/2017 - 01/2016
2	Alcoholic Fatty Liver 02/2016 - 11/2011
2	Carcinogenesis 02/2016 - 02/2014
2	Hypertension (High Blood Pressure) 01/2016 - 01/2016
2	Heart Failure 01/2016 - 01/2016
2	Aortic Arch Aneurysm 01/2006 - 12/2002
2	Aneurysm (Aneurysms) 01/2006 - 12/2002
1	Liver Failure 01/2022
1	Death (Near-Death Experience) 01/2020
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020
1	Anterior Uveitis 04/2019
1	Lipodystrophy 01/2017
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017
1	Hyperplasia 01/2017
1	Neoplasms (Cancer) 01/2017
1	Hepatocellular Carcinoma (Hepatoma) 02/2016
1	Diabetes Mellitus 01/2016
1	Hypoglycemia (Reactive Hypoglycemia) 01/2016
1	Edema (Dropsy) 01/2016

Drug/Important Bio-Agent (IBA)

11	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 07/2011
3	Insulin ReceptorIBA 10/2020 - 02/2014
3	3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanolIBA 10/2020 - 01/2017
3	Insulin (Novolin)FDA Link 10/2020 - 11/2011
3	Triglycerides (Triacylglycerol)IBA 12/2017 - 07/2012
3	Prorenin ReceptorIBA 06/2017 - 06/2014
2	IGF Type 1 Receptor (IGF 1 Receptor)IBA 10/2020 - 01/2017
2	CholesterolIBA 01/2020 - 12/2017
2	Blood Glucose (Blood Sugar)IBA 12/2017 - 02/2016
2	Liraglutide FDA Link 12/2017 - 07/2012
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2016
2	LipidsIBA 02/2016 - 07/2012
2	GlucokinaseIBA 01/2016 - 05/2014
2	Levofloxacin (Levaquin)FDA Link 12/2015 - 06/2014
2	Insulin Receptor Substrate ProteinsIBA 05/2014 - 02/2014
1	CanagliflozinIBA 11/2021
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 11/2021
1	C-Reactive ProteinIBA 11/2021
1	Nonesterified Fatty Acids (NEFA)IBA 10/2020
1	LinagliptinIBA 10/2020
1	Dipeptidyl-Peptidase IV InhibitorsIBA 10/2020
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020
1	SolutionsIBA 01/2020
1	HydrogenIBA 01/2020
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	1,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA 01/2020
1	SphingolipidsIBA 01/2020
1	4-hydroxyphenylethanolIBA 04/2019
1	Dinoprostone (PGE2)FDA Link 04/2019
1	Proteins (Proteins, Gene)FDA Link 04/2019
1	Valine (L-Valine)FDA Link 01/2019
1	Leucine (L-Leucine)FDA Link 01/2019
1	Branched-Chain Amino AcidsIBA 01/2019
1	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 01/2019
1	Isoleucine (L-Isoleucine)FDA Link 01/2019
1	Vascular Endothelial Growth Factor CIBA 01/2019
1	Thioctic Acid (Lipoic Acid)IBA 01/2019
1	rebamipideIBA 07/2018
1	AlarminsIBA 01/2018
1	Calcium-Binding ProteinsIBA 01/2018
1	Adenosine Triphosphate (ATP)IBA 12/2017
1	LDL CholesterolIBA 12/2017
1	Oxidoreductases (Dehydrogenase)IBA 12/2017
1	Tricarboxylic AcidsIBA 12/2017
1	Biomarkers (Surrogate Marker)IBA 12/2017
1	Pyruvic Acid (Pyruvate)IBA 12/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 01/2017
1	Streptozocin (Streptozotocin)FDA Link 02/2016
1	ReninIBA 01/2016
1	Sucrose (Saccharose)IBA 01/2016
1	TabletsIBA 01/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2016
1	miglitol (Glyset)FDA Link 01/2016
1	Diazoxide (Hyperstat)FDA Link 01/2016
1	Linoleic Acid (Linoleate)IBA 01/2016
1	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 01/2016
1	Phosphates (Orthophosphate)IBA 12/2015
1	Polymyxins (Polymyxin)IBA 06/2014
1	Ophthalmic Solutions (Eye Drops)IBA 06/2014

Therapy/Procedure

3	Transplantation 01/2022 - 01/2019
2	Slit Lamp 06/2014 - 05/2013
2	Sternotomy 01/2006 - 12/2002
2	Stents 01/2006 - 12/2002
2	Sutures (Suture) 01/2006 - 12/2002
1	Minimally Invasive Surgical Procedures 06/2019
1	Heart Transplantation (Grafting, Heart) 01/2016